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Inhibition of porphobilinogen synthase (PBG-synthase) by 4,6-dioxoheptanoic acid (1) and related compounds

Frédéric Stauffer, Caroline Jarret, Thomas Engeloch, Matthias Henz, Janette Bobalova and Reinhard Neier*

Department of Chemistry, University of Neuchâtel, CH-2000 Neuchâtel , (Switzerland)


We are investigating the mechanism of PBG-synthase by active site directed inhibition studies. The procedure for testing and the data obtained with compounds related to 4,6-dioxoheptanoic acid (1) are reported and the results are discussed in the context of our kinetic model.

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