Prof. Klaus Bernauer

Institut de Chimie
Université de Neuchâtel
Av.
Bellevaux 51
CH-2000 NEUCHÂTEL
Switzerland


e-mail:Klaus.Bernauer@unine.ch

 


Studies:


1954 - 1963

Diploma of chemistry at the University of Basel;
1958 - 1964

PhD ( phil. II ) with Prof. S. Fallab;

Research assistant of Prof. H. Erlenmeyer;
1964 - 1965

Scientific collaborator at the University of Neuchâtel;
1965 - 2000

Full professor of Inorganical and Analytical Chemistry at the University of Neuchâtel.


2000 -

Professor Emeritus at the University of Neuchâtel.


Research interests:


·         Enantioselective synthesis of amino-acids in optically active metal-complexes.

·         Stereoselectivity and electron-transfer mechanisms between metal-complexes and between metal-complexes and metalloproteins.

·         Kinetics, mechanisms and stereoselectivity in the reactions of coordination compounds.


Publications:


 

 Reduction of Ferricytochrome c Catalyzed by Optically Active Chromium(III) Complexes.

 Scholten, Ulrich; Diserens, Celine; Stoeckli-Evans, Helen; Bernauer, Klaus; Meyer, Michel; Stuppfler, Ludovic; Lucas, Dominique

 Inorganic Chemistry (2009),  48(23),  10942-10953. 

 

 The Proton Complex of a Diaza-macropentacycle: Structure, Slow Formation, and Chirality Induction by Ion Pairing with the Optically Active 1,1'-Binaphthyl-2,2'-diyl Phosphate Anion. 

 Bonnot, Clement; Chambron, Jean-Claude; Espinosa, Enrique; Bernauer, Klaus; Scholten, Ulrich; Graff, Roland.   

 Journal of Organic Chemistry  (2008),  73(20),  7871-7881

 

 (Strept)avidin as Host for Biotinylated Coordination Complexes: Stability, Chiral Discrimination, and Cooperativity.

 Loosli, Andreas; Rusbandi, Untung Edy; Gradinaru, Julieta; Bernauer, Klaus; Schlaepfer, Carl Wilhelm; Meyer, Michel; Mazurek, Sylwester; Novic, Marjana; Ward, Thomas R.   

 Inorganic Chemistry  (2006),  45(2),  660-668. 

 

 Electron-transfer-mediated binding of optically active cobalt(III) complexes to horse heart cytochrome c. 

 Scholten, Ulrich; Merchan, Alejandro Castillejo; Bernauer, Klaus

 Journal of the Royal Society, Interface  (2005),  2(2),  109-112. 

 

 Non-linear effects in asymmetric reactions: Negative and positive stereoselectivity in the formation of homoleptic 1:2 metal to ligand complexes of chiral 1,9-disubstituted semicorrin ligands. 

 Guicher, Nathalie; Stoeckli-Evans, Helen; Bernauer, Klaus

 Chimia  (2003),  57(10),  581-585. 

 

 Iron, cobalt, nickel and ruthenium complexes of 2,6-bis(3,4-dihydro-2H-pyrrol-5-yl)pyridine, a pybox analogue. 

 Cabort, Amel; Michel, Armelle; Therrien, Bruno; Stoeckli-Evans, Helen; Bernauer, Klaus; Suss-Fink, Georg; Williams, Alan F.; Stupka, Gilles.   

 Inorganica Chimica Acta  (2003),  350  193-200. 

 

 Copper(II) azido complexes containing trinitrogen ligands: [Cu(h 3-L)(N3)]2[Cu2Cl2(N3)4] [L = 2,6-bis(3,4-dihydro-2H-pyrrol-5-yl)pyridine], a tridimensional network of cationic and anionic copper complexes. 

 Cabort, Amel; Therrien, Bruno; Bernauer, Klaus; Suss-Fink, Georg.  

 Inorganica Chimica Acta  (2003),  349  78-84. 

 

 Ligand dehydrogenation in ruthenium trinitrogen complexes: synthesis, structure and chirality of the cations [Ru(LH4)(L)]2+ [LH4=2,6-bis(pyrrolidin-2-yl)pyridine]. [Erratum to document cited in CA138:116799]. 

 Cabort, Amel; Therrien, Bruno; Stoeckli-Evans, Helen; Bernauer, Klaus; Suss-Fink, Georg.  

 Inorganic Chemistry Communications  (2002),  5(10),  913. 

 

 Ligand dehydrogenation in ruthenium trinitrogen complexes: synthesis, structure and chirality of the cations [Ru(LH4)(L)]2+ [LH4 = 2,6-bis(pyrrolidin-2-yl)pyridine]. 

 Cabort, Amel; Therrien, Bruno; Stoeckli-Evans, Helen; Bernauer, Klaus; Suss-Fink, Georg. 

  Inorganic Chemistry Communications  (2002),  5(10),  787-790. 

 

 [2,6-Bis(3,4-dihydro-2H-pyrrol-5-yl)pyridine]trichlororhodium(III) dibenzene solvate. 

 Cabort, Amel; Therrien, Bruno; Bernauer, Klaus; Suess-Fink, Georg. 

 Acta Crystallographica, Section E: Structure Reports Online  (2002),  E58(10),  m564-m565. 

 

 [RuCl{2,6-bis(3,4-dihydro-2H-pyrrol-5-yl)pyridine}(PPh3)2]BF4 dichloromethane solvate. 

 Cabort, Amel; Therrien, Bruno; Bernauer, Klaus; Suess-Fink, Georg. 

 Acta Crystallographica, Section E: Structure Reports Online  (2002),  E58(10),  m557-m558. 

 

 Carbonate binding to copper(II) in solution: mixed-ligand complex formation and its application to the isolation and separation of the three isomers of [Cu(bpp)(H2O)][ClO4]2 [bpp = 2,6-bis(pyrrolidin-2-yl)pyridine].  

 Bernauer, Klaus; Cabort, Amel; Guicher, Nathalie; Stoeckli-Evans, Helen; Suess-Fink, Georg.   

 Journal of the Chemical Society, Dalton Transactions  (2002),   (9),  2069-2073

 

 Chiral metal complexes as probes in electron-transfer reactions involving metalloproteins. 

 Bernauer, K.; Ghizdavu, S.; Verardo, L.   

 Coordination Chemistry Reviews  (1999),  190-192  357-369. 

 

 Stereo- and site selection by enantiomers in electron-transfer reactions involving native and recombinant metalloproteins. 

 Bernauer, Klaus; Schurmann, Peter; Nusbaumer, Charly; Verardo, Luca; Ghizdavu, Simona.  

 Pure and Applied Chemistry  (1998),  70(4),  985-991. 

 

 Stereoselectivity in reactions of metal complexes. Part XXII. Kinetics and mechanism of electron-transfer reactions between rac-[Co(L)X]+ (L=[(pyridine-2,6-diyl)bis(methylene)]bis[amino acid]; X=pyridine, imidazole, 1-methylimidazole and pyrazine) and optically active iron(II) complexes. 

 Hilgers, Hermann Josef; Bernauer, Klaus. 

 Inorganica Chimica Acta  (1998),  275-276(1,2),  9-14. 

 

 Stereoselectivity in reactions of metal complexes. Part XXI. Kinetics and mechanism of electron transfer between rac-[Co(L)H2O]+ (L=N,N'-[(pyridine-2,6-diyl)bis(methylene)]bis[amino acid]) and optically active iron(II) complexes. 

 Bernauer, Klaus; Hugi-Cleary, Deirdre; Hilgers, Hermann Josef; Abd-el-Khalek, Habib; Brugger, Nadia; Kressl, Claudia.   

 Inorganica Chimica Acta  (1998),  275-276(1,2),  1-8. 

 

 Stereoselectivity and mechanism of Cu2+ transfer between chiral, multidentate ligands. 

 Bernauer, Klaus; Gilet, Marie-Fabiola.   

 Chemical Communications (Cambridge)  (1997),   (14),  1287-1288

 

 Stereo- and site selection by enantiomers in electron-transfer reactions involving native and recombinant metalloproteins. 

 Bernauer, K..   

 Journal of Inorganic Biochemistry  (1997),  67(1-4),  400. 

 

 Unexpected kinetic stability of a dinuclear helical complex. 

 Charbonniere, Loiec J.; Gilet, Marie-Fabiola; Bernauer, Klaus; Williams, Alan F.  

 Chemical Communications (Cambridge)  (1996),   (1),  39-40. 

 

 CHiral2-Workshop.  

 Bernauer, K..  

 Chimia  (1995),  49(7-8),  314. 

 

 Modification of layer silicates by sterically demanding metal complexes: synthesis and intercalation of the square planar complexes [Cu(bppep)(H2O)](ClO4)2 and [Ni(bppep)(Cl)]Cl (bppep = 2,6-bis[1-phenyl-1-(pyridine-2-yl)ethyl]pyridine) in hectorite.  

 Meister, Annette; Takano, Nakoho; Chuard, Thierry; Graf, Marion; Bernauer, Klaus; Stoeckli-Evans, Helen; Suess-Fink, Georg.  

 Zeitschrift fuer Anorganische und Allgemeine Chemie  (1995),  621(1),  117-21

 

 Stereoselectivity in reactions of metal complexes. Part XVIII. Kinetics and stereoselectivity in electron-transfer reactions between [Co(L)H2O]+ (L = N, N '-[(pyridine-2,6-diyl)bis(methylene)]bis[proline] (prompt) and N, N '-[(4-methoxypyridine-2,6-diyl)bis(methylene)]bis[proline] (MeO-prompt) and optically active iron(II) complexes.

 Bernauer, Klaus; Fuchs, Evelyne; Hugi-Cleary, Deirdre.  .

 Inorganica Chimica Acta  (1994),  218(1-2),  73-9. 

 

 Stereoselectivity in reactions of metal complexes. Part XVII. Synthesis of three new optically active triamines: 2,6-bis{[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]methyl}pyridine, 2,6-bis{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]methyl}pyridine, and 2,6-bis{{(2S)-2-[(benzyloxy)methyl]pyrrolidin-1-yl}methyl}pyridine. X-ray structure and equilibrium behavior of their copper(II) complexes.

 Bernauer, Klaus; Chuard, Thierry; Stoeckli-Evans, Helen.   

 Helvetica Chimica Acta  (1993),  76(6), 

 

 Stereoselectivity in reactions of metal complexes. XIX. Enantioselective formation of amino acids by isomerization of mixed ligand copper(II) Schiff-base complexes.  

 Chuard, Thierry; Gretillat, Francois; Bernauer, Klaus.  

 Chimia  (1993),  47(6),  215-17. 

 

 Stereoselectivity in reactions of metal complexes. XX. Chiral recognition and stereoselective reduction of horse ferricytochrome c by optically active iron(II) complexes. 

 Bernauer, Klaus; Jauslin, Pascal.   

 Chimia  (1993),  47(6),  218-20. 

 

 Stereoselectivity in reactions of metal complexes. Part XVI. Structure and highly stereoselective formation of 1:2 metal-to-ligand complexes with the triamine 2,6-bis(pyrrolidin-2-yl)pyridine. meso-[2,6-Bis(pyrrolidin-2-yl)pyridine]nickel(II) (meso-[Ni(bpp)2]2+), a metal complex with S4 symmetry. 

 Bernauer, Klaus; Gretillat, Francois; Stoeckli-Evans, Helen; Warmuth, Ruth.   

 Helvetica Chimica Acta  (1993),  76(1),  545-56. 

 

 Stereoselectivity in reactions of metal complexes.  Part XV.  Structure and stability of chiral cobalt(III) complexes with pentadentate ligands. 

 Bernauer, Klaus; Stoeckli-Evans, Helen; Hugi-Cleary, Deirdre; Hilgers, Hermann J.; Abd-el-Khalek, Habib; Porret, Joelle; Sauvain, Jean Jacques.      

 Helvetica Chimica Acta  (1992),  75(7),  2327-9. 

 

 Stereoselectivity in reactions of metal complexes.  Part XIV.  Use of circular dichroism to determine the stereoselective formation of [M(his)2] and [M(PhEt-sal)2] (M = nickel(II), copper(II), his = histidine, PhEt-sal = N-(1-phenylethyl)salicylaldimine).        Bernauer, Klaus; Bourqui, Stephanie; Hugi-Cleary, Deidre; Warmuth, Ruth.   

 Helvetica Chimica Acta  (1992),  75(4),  1288-96. 

 

 Stereoselective effects in electron transfer reactions involving synthetic metal complexes and metalloproteins. 

 Bernauer, Klaus.     

 Metal Ions in Biological Systems  (1991),  27  265-89. 

 

 Stereoselectivity in reactions of metal complexes.  XIII.  Stereoselectivity and chiral recognition in the electron-transfer reaction between spinach ferredoxin and optically active cobalt(III) complexes.   

 Bernauer, Klaus; Monzione, Michel; Schuermann, Peter; Viette, Veronique.  

 Helvetica Chimica Acta  (1990),  73(2),  346-52. 

 

 L-Porretine (L-3-carboxy-1,2,3,4-tetrahydroisoquinoline) as chiral selector for the resolution of chiral a -amino acids. 

 Jeanneret-Gris, G.; Porret, J.; Bernauer, K..  

 Chromatographia  (1990),  29(9-10),  449-52. 

 

 Mechanistic study of the isomerization of allyl alcohol to propionaldehyde using the cluster anion [HRu3(CO)11]- as catalyst. 

 Langenbahn, Meinhard; Bernauer, Klaus; Suess-Fink, Georg.   

 Journal of Organometallic Chemistry  (1989),  379(1-2),  165-70. 

 

 Stereoselectivity in reactions of metal complexes.  Part XI.  2,6-Bis(pyrrolidin-2-yl)pyridine:  synthesis and resolution of the meso and the optically active isomers.  Complex formation with copper(II) ion in aqueous solution. 

 Bernauer, Klaus; Gretillat, Francois.   

 Helvetica Chimica Acta  (1989),  72(3),  477-81. 

 

 Stereoselectivity in reactions of metal complexes.  Part X.  Kinetics and stereoselectivity of the inner-sphere electron-transfer reaction between [Co(bamap)H2O]+ [bamap = 2,6-bis(3-carboxy-1,2-dimethyl-2-azapropyl)pyridine] and optically active iron(II) complexes. 

 Bernauer, Klaus; Pousaz, Philippe; Porret, Joelle; Jeanguenat, Andre.  

 Helvetica Chimica Acta  (1988),  71(5),  1339-48. 

 

 Stereoselectivity in the reaction of spinach plastocyanin with optically active reducing agents. 

 Bernauer, Klaus; Sauvain, Jean Jacques.   

 Journal of the Chemical Society, Chemical Communications  (1988),   (5),  353-4. 

 

 The crystal structure of racemic and meso-diastereoisomers of aqua[2,6-bis(3-carboxy-1,2-dimethyl-2-azapropyl)pyridine]cobalt(III).hexafluorophosphate.di- and monohydrate, respectively. 

 Stoeckli-Evans, Helen; Brehm, Lotte; Pousaz, Philippe; Bernauer, Klaus; Buergi, Hans Beat.  

 Helvetica Chimica Acta  (1985),  68(1),  185-91. 

 

 Quantitation of the enantiomers of b -hydroxyamino acids by gas chromatographic resolution on an optically active packed column. 

 Su, Heng; Bernauer, Klaus.   

 Journal of Chromatography  (1984),  301(2),  461-4. 

 

 Stereoselectivity in reactions of metal complexes.  IX.  Stereoselective formation of cobalt(III) complexes with new linear pentadentate ligands. 

 Bernauer, Klaus; Pousaz, Philippe.   

 Helvetica Chimica Acta  (1984),  67(3),  796-803. 

 

 Stereoselectivity in reactions of metal complexes.  VIII.  Asymmetric synthesis of some amino acids by stereoselective transamination of aliphatic keto acids in mixed ligand copper(II)-Schiff-base complexes. 

 Deschenaux, Robert; Bernauer, Klaus.   

 Helvetica Chimica Acta  (1984),  67(2),  373-7. 

 

 Stereoselectivity in reactions of metal complexes.  VII.  Asymmetric synthesis of amino acids by metal ion-promoted transamination. 

 Bernauer, Klaus; Deschenaux, Robert; Taura, Toshiaki.   

 Helvetica Chimica Acta  (1983),  66(7),  2049-58. 

 

 

 Base catalyzed racemization of ethylenediamine-N,N,N'-triacetatoaquacobalt(III). 

 Bernhard, C. A.; Bernauer, K..   

 Helvetica Chimica Acta  (1977),  60(7),  2371-8. 

 

 Stereoselectivity in reactions of metal complexes.  V.  Synthesis of mixed-ligand cobalt(III) complexes with (S)-aspartic-N-monoacetic acid and different amino acids. 

  Colomb, Gerard; Bernauer, Klaus.   

Helvetica Chimica Acta  (1977),  60(2),  459-67. 

 

 Stereoselectivity in reactions of metal complexes.  VI.  Kinetic study of the interconversion of cis-N and trans-N (S)-aspartato-N-acetato(amino-acidato)cobalt(III) complexes. 

 Colomb, Gerard; Bernauer, Klaus.   

 Helvetica Chimica Acta  (1977),  60(2),  468-74. 

 

 Diastereoisomerism and diastereoselectivity in metal complexes. 

 Bernauer, Klaus.

 Topics in Current Chemistry  (1976),  65(Theor. Inorg. Chem. 2),  1-35. 

 

 Stereoselectivity in reactions of metal complexes.  IV.  Asymmetric synthesis of (2R, 7S, 10R)- and (2R, 7R, 10R)-2,10-diamino-5,5,7-trimethyl-4,8-diazaundecanenickel(II) by stereoselective hydrogenation of (2R, 10R)-2, 10-diamino-5,5,7-trimethyl-4,8-diaza-7-undecenenickel(II). 

 Guentert, Bruno; Claude, Saturnin; Bernauer, Klaus.   

 Helvetica Chimica Acta  (1975),  58(3),  780-7. 

 

 Stereoselectivity in complexes of amino acids and related compounds. 

 Bernauer, Klaus.  

 Metal Ions in Biological Systems  (1974),  1  117-28. 

 

 Stereoselective effects in reactions of metal complexes.  III.  Asymmetric hydrogenation of (5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene) nickel(II). 

 Wermeille, Maurice; Sledziewska, Ewa; Bernauer, Klaus.   

 Helvetica Chimica Acta  (1974),  57(1),  180-7. 

 

Separating racemates using column chromatography on optically acitive metal complexes.   

 Bernauer, Klaus.  (Lonza Ltd.).    Patentschrift (Switz.)  (1971),     2 pp. 

 CODEN: SWXXAS  CH  509239  19710813  Application: CH  69-509239  19690321.

 

 Asymmetric nitrogen.  Racemization and deuterium exchange in macrocyclic complexes.   

 Sledziewska, E.; Plachta, L.; Vonderschmitt, D.; Bernauer, K..   

 Chimia  (1971),  25(10),  330-2. 

 

 Stereoselective effects in reactions of metal complexes.  II.  Selectivity in the complex formation of nickel(II)-, copper(II)- and zinc(II)-(D)-propylenediaminetetraacetate with racemic 1-phenylethylamine. 

 Bernauer, Klaus; Jeanneret, M. F.; Vonderschmitt, D.   

 Helvetica Chimica Acta  (1971),  54(1),  297-302. 

 

 Separation of racemic mixtures by chromatography on an optically active support. 

 Bernauer, Klaus.  (Lonza Ltd.).    Patentschrift (Switz.)  (1970),     2 pp. 

 CODEN: SWXXAS  CH  490292  19700630  Application: CH  68-490292  19680322. 

 

 Organometallic compounds.  IV.  Stability and nature of the bonds of some organotin complexes. 

 Affolter, Jean; Jacot-Guillarmod, Andre; Bernauer, Klaus.   

 Helvetica Chimica Acta  (1968),  51(2),  293-300. 

 

 Organometallic compounds.  III.  Reaction of organomagnesium compounds with titanium tetrachloride complexes.  

 Boustany, Kamel S.; Bernauer, Klaus; Jacot-Guillarmod, Andre.   

 Helvetica Chimica Acta  (1967),  50(5),  1305-13. 

 

 Organometallic compounds.  I.  Action of benzylmagnesium chloride and phenylmagnesium bromide on titanium tetrachloride. 

 Boustany, Kamel S.; Bernauer, Klaus; Jacot-Guillarmod, Andre.   

 Helvetica Chimica Acta  (1967),  50(4),  1080-4. 

 

 Reactivity of coordination compounds. XIV. Reversible fixation of oxygen to iron(II) phthalocyaninetetrasulfonic acid. 

 Vonderschmitt, D.; Bernauer, Klaus; Fallab, S.   

 Helvetica Chimica Acta  (1965),  48(4),  951-4. 

 

 Phthalocyanine in aqueous solution. IV. Kinetics and mechanism of metal complex formation. 

 Schiller, I.; Bernauer, Klaus.   

 Helvetica Chimica Acta  (1963),  46(7),  3002-7. 

 

 Phthalocyanines in aqueous solution. III. Acid dissociation of the pyrrole NH group in phthalocyaninetetrasulfonic acid. 

 Bernauer, Klaus; Fallab, S.   

 Helvetica Chimica Acta  (1962),  45  2487-94. 

 

 Phthalocyanine in aqueous solution. The mechanism of metal complex formation. 

 Schiller, I.; Bernauer, K.; Fallab, S.  

 Experientia  (1961),  17  540. 

 

 Phthalocyanines in aqueous solution. 

 Bernauer, Klaus; Fallab, S

 Helvetica Chimica Acta  (1961),  44  1287-92. 

 

Stability and kinetics by complex formation reactions. VIII. Polarographic behavior of several zinc and cadmium complexes. 

 Bernauer, K.; Walz, D.; Fallab, S.  

 Helvetica Chimica Acta  (1958),  41  2094-9. 

 

 The complexing ability of 1,3-dihydroxyacetone and similar compounds. 

 Bernauer, Klaus; Fallab, S.  

 Helvetica Chimica Acta  (1957),  40  1690-4. 

 

 Stability and kinetics of complex formation. VI. The properties of the N,N-dipropyldithiocarbamate-nickel complexes. 

 Bernauer, K.; Fallab, S.; Erlenmeyer, H.  

 Helvetica Chimica Acta  (1956),  39  1993-6. 

 

 



Scientific Collaborations

Prof. Helen Stoeckli-Evans University of Neuchâtel, Switzerland.

Prof. P. Schürmann, Biochemistry Department, University of Neuchâtel, Switzerland.

Prof. A. Williams, University of Geneva, Switzerland.

Prof. A. Merbach, University of Lausanne, Switzerland.

Dr. T. Grell , Max Planck Institute, Frankfurt, Germany.